publications

First BIG N2N paper published

On June 20th, the first paper bearing the affiliation "Bioinformatics Institute Ghent" was published in BMC Bioinformatics.

http://www.biomedcentral.com/1471-2105/16/197

Jan M. Ruijter, Steve Lefever, Jasper Anckaert, Jan Hellemans, Michael W. Pfaffl, Vladimir Benes, Stephen A. Bustin, Jo Vandesompele, Andreas Untergasser and on behalf of the RDML consortium (2015) RDML-Ninja and RDMLdb for standardized exchange of qPCR data. BMC Bioinformatics, 16:197

accepted paper: SNP-guided identification of monoallelic DNA-methylation events from enrichment-based sequencing data

Monoallelic gene expression is typically initiated early in the development of an organism. Dysregulation of monoallelic gene expression has already been linked to several non-Mendelian inherited genetic disorders. In humans, DNA-methylation is deemed to be an important regulator of monoallelic gene expression, but only few examples are known. One important reason is that current, cost-affordable truly genome-wide methods to assess DNA-methylation are based on sequencing post enrichment.

Analysis of 41 plant genomes supports a wave of successful genome duplications in association with the Cretaceous–Paleogene boundary

In 2009, the Van de Peer lab proposed a correlation between whole genome duplications in plants and the Cretaceous-Paleogene extinction event, the most recent mass extinction, which wiped out 70% of all life on earth, including the dinosaurs. Since this finding was met with some skepticism, the researchers have revisited this hypothesis, using 40 whole genome sequences and the most sophisticated evolutionary models and dating techniques available, and ... the story still stands.

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