Network biology

ASP-G: an ASP-based method for finding attractors in genetic regulatory networks

Boolean network models are suitable to simulate GRNs in the absence of detailed kinetic information. However, reducing the biological reality implies making assumptions on how genes interact (interaction rules) and how their state is updated during the simulation (update scheme). The exact choice of the assumptions largely determines the outcome of the simulations. In most cases, however, the biologically correct assumptions are unknown. To allow for a more flexible simulation framework, we developed ASP-G.

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