translational bioinformatics

A Functional and Evolutionary Perspective on Transcription Factor Binding in Arabidopsis thaliana

Understanding the mechanisms underlying gene regulation is paramount to comprehend the translation from genotype to phenotype. The two are connected by gene expression, and it is generally thought that variation in transcription factor (TF) function is an important determinant of phenotypic evolution. We analyzed publicly available genome-wide chromatin immunoprecipitation experiments for 27 TFs in Arabidopsis thaliana and constructed an experimental network containing 46,619 regulatory interactions and 15,188 target genes.

Jan/19 09:00 - Jan/23 17:00
NIHR Biomedical Research Centre at Guy's and St Thomas' and King's College London Location: Floor 16, Tower Wing, Guy's Hospital , London SE1 9RT, United Kingdom

Translational Bioinformatics Workshop

Key note speaker: Prof. Tim Hubbard (Wellcome Trust Sanger Institute)

Workshop Director: Dr. Emanuele de Rinaldis, Biomedical Research Centre at Guy’s and St Thomas’ and King’s College of London’s Cancer Division

Places are now available on the Translational Bioinformatics Workshop, led by NIHR Biomedical Research Centre at Guy’s & St Thomas’ and King's College London.

Apr/01 09:00 - Apr/02 18:00
Virginie Lovelingbuilding (VAC Gent) Koningin Maria Hendrikaplein 70 - 9000 Gent

From big data to bedside

Big datasets generated on the newest “omics” platforms significantly help in establishing a comprehensive view and understanding of tumor biology. At the same time, the handling and mining of these data sets poses great bioinformatic challenges. The complexity and size of these datasets is overwhelming and novel bioinformatic tools are being developed at a rapid pace to ensure fast and powerful analyses.


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