A web application for sample size and power calculation in case-control microbiome studies
When designing a case-control study to investigate differences in microbial composition, it is fundamental to assess the sample sizes needed to detect an hypothesised difference with sufficient statistical power. Our application includes power calculation for (i) a recoded version of the two-sample generalised Wald test of the “HMP” R-package for comparing community composition, and (ii) the Wilcoxon-Mann-Whitney test for comparing OTU-specific abundances between two samples (optional).