Apr/09 11:00 - Apr/09 12:00
Jozef Schell seminar room Technologiepark 927 B-9052 Gent

N2N seminar: Long non-coding RNAs as a source of new peptides

When we annotate a new genome we always find genes that have no homologues in other species. These genes, called “orphans”, play important roles in the adaptation of the organism to the environment, but their origin has remained a mystery. The development of deep transcriptome sequencing (RNAseq) is providing new insights into this question. We and others have found that many transcrips expressed at low levels and with little coding potential, the so called long non-coding RNAs, associate with ribosomes and translate short peptides.


A comprehensive compendium of long non-coding RNAs.
Long non-coding RNA (lncRNA) constitutes a large and diverse class of non-coding RNA genes. While several lncRNAs have been functionally annotated, the majority remains to be characterized. Different high-throughput methods to identify new lncRNAs (including RNA sequencing and annotation of chromatin-state maps) have been applied in various studies resulting in multiple unrelated lncRNA datasets.


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