lncRNAs

PhD Pieter-Jan Volders: Exploring lncRNAs in cancer: tools for discovery and characterization of cancer associated lncRNAs

Long non-coding RNAs (lncRNAs) form a new class of genes that outnumbers any other class of RNAs predicted in the human genome. Since most lncRNA annotation is relatively new, lncRNAs are underrepresented in the established genomic databases and on the commercially available platforms. To address this issue, I collected human lncRNA annotation from different sources and developed the public lncRNA database LNCipedia (www.lncipedia.org) in the first months of my PhD.

The Notch driven long non-coding RNA repertoire in T-cell acute lymphoblastic leukemia

Genetic studies in T-cell acute lymphoblastic leukemia have uncovered a remarkable complexity of oncogenic and loss-of-function mutations. Amongst this plethora of genetic changes, NOTCH1 activating mutations stand out as the most frequently occurring genetic defect, identified in more than 50% of T-cell acute lymphoblastic leukemias, supporting a role as an essential driver for this gene in T-cell acute lymphoblastic leukemia oncogenesis. In this study, we aimed to establish a comprehensive compendium of the long non-coding RNA transcriptome under control of Notch signaling.

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