Genomics

EXPLoRA-web: linkage analysis of quantitative trait loci using bulk segregant analysis

Identification of genomic regions associated with a phenotype of interest is a fundamental step toward solving questions in biology and improving industrial research. Bulk segregant analysis (BSA) combined with high-throughput sequencing is a technique to efficiently identify these genomic regions associated with a trait of interest.

Needles: Toward Large-Scale Genomic Prediction with Marker-by-Environment Interaction

Genomic prediction relies on genotypic marker information to predict the agronomic performance of future hybrid breeds based on trial records. Because the effect of markers may vary substantially under the influence of different environmental conditions, marker-by-environment interaction effects have to be taken into account. However, this may lead to a dramatic increase in the computational resources needed for analyzing large-scale trial data. A high-performance computing solution, called Needles, is presented for handling such data sets.

Sep
15
Sep/15 09:00 - Sep/16 18:00
Ugent – PAC Zuid (Woodrow Wilsonplein, 9000 Gent)

Light on the Dark Side of the Genome

The human genome encodes the blueprint of life using only 2% of its nearly three billion bases to code for approximately 20,000 genes. The remaining portion is often referred to as “junk” DNA. Over the past decade, advances in genomic technologies and initiatives like the ENCODE and the Roadmap Epigenomics projects, revealed that these regions encrypt a regulatory code accommodating numerous key elements (e.g. enhancers, non-coding RNA,…) necessary to orchestrate the regulatory complexity of gene expression patterns.

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