Comparative genomics

COMODO v2.0: COnserved MODules across Organims

COMODO v2.0 uses an objective selection criterium to identify conserved expression modules between three species (in contrast to its previous version which could only handle two species). The method uses as input microarray data and a gene homology map and provides as output pairs of conserved modules (Figure 1). COMODO v2.0 searches for module combinations in the species being compared, for which the number of sharing homologs is statiscally most significant relative to the size of the linked modules.

Feb
11
Feb/11 11:00
Jozef Schell seminar room UGent-VIB Research Building FSVM Technologiepark 927 B-9052 Zwijnaarde (Gent)

BIG N2N seminar by Prof. Marek Mutwil: Gene module multiplication drives pathway expansion in plants

The survival of species depends on their ability to adapt to new environments. Adaptive innovations require genetic material, mainly provided by gene duplications, which can lead to new or alternative pathways. However, the principles behind the emergence of such pathways are not understood. Here, we show that approximately one third of the genes of a plant’s genome participate in hundreds of alternative pathways, which were primarily generated by single gene duplications.

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