BIG N2N Seminar by Prof. Ben Lehner, EMBL-CRG Systems Biology Unit, Centre for Genomic Regulation, Barcelona, Spain
J. Schell seminar room
UGent-VIB Research building FSVM
9052 Zwijnaarde (Gent)
Since Darwin and Lamarck, biologists have been intrigued by the possibility of the inheritance of acquired traits. In our work on the causes of inter-individual variation we chanced upon an example of a >10 generation epigenetic memory of environmental change in C. elegans. We have been using this as a model system to understand how information about the environment can be transmitted for many generations without establishing permanent epigenetic states. I will present this work and I will also show how impaired DNA replication during development can lead to genome-wide epigenetic reprogramming.