BIG N2N Seminar by Dr. Pieter Mestdagh
J Schell seminar room
UGent-VIB Research Building FSVM
9052 Zwijnaarde (Gent)
Until recently, it was believed that only a small fraction of the genome contained relevant information, used by the cell to produce proteins. The majority was referred to as ‘junk DNA’ with no obvious function throughout life. The introduction of massively parallel RNA-sequencing technology has drastically changed that view. Today, there’s ample evidence demonstrating that the majority of the genome is transcribed, producing non-coding RNA (ncRNA) transcripts that differ in size, shape, expression and function. The bulk of the non-coding transcriptome consists of so-called long non-coding RNAs (lncRNAs). These lncRNAs are characterized by an exquisite tissue-specificity of lncRNAs which makes them extremely attractive as targets for therapeutic intervention or biomarkers for disease diagnosis and treatment response monitoring.