Apr 23

Cancer progression is an evolutionary process characterized by the accumulation of mutations and responsible for tumor growth, clinical progression, and drug resistance development. We discuss how to reconstruct the evolutionary history of a tumor from single-cell sequencing data. The tumor phylogeny problem is challenging because of sequencing errors and the high rate of allelic drop-out in single cell DNA sequencing experiments. We present a probabilistic model and a Markov Chain Monte Carlo approach to learn tumor phylogenies from such data.